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Gene Duplication: A Drive for Phenotypic Diversity and Cause of Human Disease

✍ Scribed by Conrad, Bernard; Antonarakis, Stylianos E.

Book ID
118188279
Publisher
Annual Reviews
Year
2007
Tongue
English
Weight
278 KB
Volume
8
Category
Article
ISSN
1527-8204

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✍ Xiuyuan Hu; Ronald G. Worton πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 902 KB

Tandem duplication of large regions of DNA, including duplication of whole genes, provides a substrate for genetic evolution. Tandem duplication of smaller regions involving parts of genes is now recognized as a contributor to the mutation spectrum that results in genetic disease. In this review, mo