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Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes

✍ Scribed by Ordóñez, D; Meenagh, A; Gómez-Lozano, N; Castaño, J; Middleton, D; Vilches, C

Book ID
109852798
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
148 KB
Volume
9
Category
Article
ISSN
1466-4879

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## Abstract Killer‐cell Ig‐like receptors (KIR) are structurally and functionally diverse, and enable human NK cells to survey the expression of individual HLA class I molecules, often altered in infections and tumors. Multiple events of non‐reciprocal recombination have contributed to the rapid di