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Gene delivery to in situ veins: Differential effects of adenovirus and adeno-associated viral vectors

✍ Scribed by Eslami, Mohammad H.; Gangadharan, Sidhu P.; Sui, XinXin; Rhynhart, Kurt K.; Snyder, Richard O.; Conte, Michael S.

Book ID: 122112738
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 218 KB
Volume: 31
Category: Article
ISSN: 1097-6809
DOI: 10.1016/S0741-5214(00)90105-8

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## Abstract ## Background The success of gene therapy for inherited neurodegenerative diseases such as metachromatic leukodystrophy (MLD) depends on the development of efficient gene delivery throughout the brain guarded by the blood–brain barrier and achieves distribution of the deficient enzyme