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Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat

โœ Scribed by Thorsten G. Lehmann; Michael D. Wheeler; Robert F. Schwabe; Henry D. Connor; Robert Schoonhoven; Hartwig Bunzendahl; David A. Brenner; R.Jude Samulski; Zhi Zhong; Ronald G. Thurman

Book ID
111721217
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
703 KB
Volume
32
Category
Article
ISSN
0270-9139

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Transplantation of reduced-size livers may lead to a hypermetabolic state and increased production of oxygen radicals. Since oxygen radicals may cause liver injury and impair liver regeneration, we tested the hypothesis that overexpression of superoxide dismutase (SOD) in reduced-size livers (RSL) w