Gene Conversion and Functional Divergence in the β-Globin Gene Family
✍ Scribed by Gabriela Aguileta; Joseph P. Bielawski; Ziheng Yang
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 374 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-2844
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We report on three novel polymorphisms in and around the β globin gene. Two of them are intronic (IVS2) polymorphisms (IVS 2 nt 200–203 (−CTTT) and IVS2 82–83 (−AG)). The third is a novel G→C substitution at nt +1707 related to the β globin cap site. This +1707 G→C polymorphism was dete
## Abstract The mammalian β‐globin locus is a multigene locus containing several globin genes and a number of regulatory elements. During development, the expression of the genes changes in a process called “switching.” The most important regulatory element in the locus is the locus control region
Thalassemia is a heterozygous inherited disorder of [3globin synthesis lying cis to the defective [3-globin gene. Over 100 thalassemia mutations have been characterized in various ethnic groups and the same mutations have been observed in different ethnic groups. The haplotypes (HT) and [3-globin ge