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Gender Difference in the Interaction of Smoking and Monoamine Oxidase B Intron 13 Genotype in Parkinson’s Disease

✍ Scribed by Samir N Kelada; Paola Costa-Mallen; Lucio G Costa; Terry Smith-Weller; Gary M Franklin; Phillip D Swanson; W.T Longstreth Jr.; Harvey Checkoway

Book ID
117330025
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
97 KB
Volume
23
Category
Article
ISSN
0161-813X

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Association of a polymorphism in intron
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## Monoamine oxidase B (MAO -B ) is an enzyme that has relevance for Parkinson disease (PD) because of its roles in catabolizing dopamine and potentially activating exogenous neurotoxicants. A polymorphism of the gene encoding MAO-B has been identified as a single base change (A or G) in intron

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## Abstract Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the __MAO B__ gene may modify the relationship between smoking and Parkinson's Disease (PD). We examined the association of MAO B intron 13 G/A polymorphism and risk of PD, and the modula