The Mayo Clinic and the North Central Cancer Treatment Group (NCCTG) conducted a randomized clinical trial comparing five different combination chemotherapeutic regimens to single-agent 5-fluorouracil (5-FU), given by intravenous bolus technique (500 mg/m2 for 5 days) as a control, in the treatment
Gemcitabine, 5-fluorouracil, and leucovorin in advanced biliary tract and gallbladder carcinoma : A North Central Cancer Treatment Group Phase II Trial
β Scribed by Steven R. Alberts; Hani Al-Khatib; Michelle R. Mahoney; Lawerence Burgart; Peter J. Cera; Patrick J. Flynn; Tom R. Finch; Ralph Levitt; Harold E. Windschitl; James A. Knost; Loren K. Tschetter
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 97 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0008-543X
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## Background: Unresectable adenocarcinoma of the biliary tree are associated with a very poor prognosis. 5-fluorouracil (5-fu) combination regimens have produced objective response rates in approximately 10-20% of patients. leucovorin increases the selective cytotoxicity of 5-fu. there also are en
To determine the feasibility and toxicity of combining leucovorin (CF) with a 5fluorouracil(5-FU) combination chemotherapy regimen currently accepted by many as standard treatment for gastric cancer, CF (500 mg/m') was administered in combination with the Georgetown S-FU, doxorubicin, and mitomycin
The current treatment of advanced urothelial carcinoma generates high response rates but is associated with poor overall survival. The current study evaluated the efficacy and toxicity of a new combination of active drugs in the treatment of urothelial carcinoma. ## METHODS. Twenty-four patients