Gel-phase synthesis of a difficult sequence peptide on 1,4-butanediol dimethacrylate-crosslinked polystyrene support
β Scribed by I. M. Krishnakumar; Beena Mathew
- Publisher
- Springer Netherlands
- Year
- 2000
- Tongue
- English
- Weight
- 627 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1573-3149
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AbstractΓA 1,4-butanediol dimethacrylate cross-linked polystyrene (PSΒ±BDODMA) support was prepared by aqueous suspension polymerization. The C-terminal amino acid incorporation, N a -Fmoc and Boc-deprotection, acylation reactions and the removal of the target peptide from the support were optimized.
A highly solvating copolymer was prepared in high yield by introducing a flexible crosslinker, 1,4-butanedioldimethacrylate, into the polystyrene matrix by a free radical aqueous suspension polymerization. A 2 mol% crosslinked resin showed rigidity and mechanical characteristics comparable to those
## Abstract A hydrophobic analogue of human galanin (1β19) fragment has been synthesized using Boc/Bzl tactics to demonstrate the synthetic utility of the flexible crosslinked polystyrene support prepared by the suspension polymerization of styrene and 1,4βbutanediol dimethacrylate. The copolymer w