✦ LIBER ✦

Gel-phase synthesis of hydrophobic [Thr14] [Thr19] Galanin (1–19) fragment on a high capacity flexible crosslinked polystyrene support

✍ Scribed by I. M. Krishna Kumar; Dr Beena Mathew

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 90 KB
Volume: 7
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.357

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✦ Synopsis

Abstract

A hydrophobic analogue of human galanin (1–19) fragment has been synthesized using Boc/Bzl tactics to demonstrate the synthetic utility of the flexible crosslinked polystyrene support prepared by the suspension polymerization of styrene and 1,4‐butanediol dimethacrylate. The copolymer was chloromethylated to 2.36 mmol Cl/g. The functionalized resin was found to possess all the physicochemical properties similar to Merrifield resin. The free peptide was obtained in high yield and purity as judged by RP‐HPLC and characterized by amino acid analysis and ESI‐MS. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.

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A highly solvating copolymer was prepared in high yield by introducing a flexible crosslinker, 1,4-butanedioldimethacrylate, into the polystyrene matrix by a free radical aqueous suspension polymerization. A 2 mol% crosslinked resin showed rigidity and mechanical characteristics comparable to those