β Scribed by J. E. L. Sales; A. H. Hunt
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Two cases of Gaucher's disease with portal hypertension are dscribed, of which one was relieved by splenectomy and the other, which had recurrent bleeding from oesophageal varices, by portacaval anastomosis. These cases demonstrate that portal hypertension in this condition may be due to increased forward portal blood-flow due to splenomegaly, to intrahepatic obstruction from extensive deposits of Gaucher cells, and probably in some cases to a combination of these factors. The case with bleeding oesophageal varices was also infantile and neither of these conditions has previously been described in Gaucher's disease.
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A 65-yr-old Japanese woman was admitted to the hospital because of hematemesis. The clinical history was negative; she drank no alcohol and did not smoke. She did not recall episodes of jaundice and had not received needle sticks or transfusions. The patient had been well until she became nauseated
EXTRAHEPATIC obstruction of the portal venous system frequently affects children and young people, some at least of whom may be expected to survive to adult life. Gibson, Johnstone, Fulton, and Rodgers (1965) suggested that the minimum objective of treatment should be to enable these patients to lea
We have read with great interest the publication by Mastai et al. (1) on the rat liver microcirculation in alcohol-induced hepatomegaly. Readers not familiar with the arguments used in this paper may interpret this work as a rebuttal of the hypothesis that hepatocyte swelling is a factor in the deve
The authors report a case of Gaucher's disease with chronic lymphocytic leukemia. The diagnosis of Gaucher's disease was confirmed by electron microscopy and glucocerebrosidase assay. There may be a pathogenetic