โ Scribed by Hector Orrego; Laurence M. Blendis; Yedy Israel
No coin nor oath required. For personal study only.
We have read with great interest the publication by Mastai et al. (1) on the rat liver microcirculation in alcohol-induced hepatomegaly. Readers not familiar with the arguments used in this paper may interpret this work as a rebuttal of the hypothesis that hepatocyte swelling is a factor in the development of portal hypertension in alcoholic liver disease (2-4). Contrary to this impression, the reported results confirm our hypothesis. Indeed, the results are those we would have predicted from our previous observations. First, that hepatocyte enlargement as observed in alcohol-induced hepatomegaly, is associated with a constriction of the vascular space (5). In fact, Mastai et al. (1) found a
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