## BACKGROUND. It is suspected that young patients with adenocarcinoma have a more aggressive form of disease and therefore a poorer prognosis than older patients. ## METHODS. A retrospective cohort study used the population-based tumor registries of Orange, San Diego, and Imperial Counties. Case
Gastric carcinoma in the young
โ Scribed by Paul L. Tso; Walter L. Bringaze III; Alton H. Dauterive; Pelayo Correa; Isidore Cohn Jr
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 392 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
โฆ Synopsis
Thirty-eight cases of gastric carcinoma in patients 35-years-old and younger, occurring in the period 1948 to 1983, are reviewed. They comprised 2.2% of 1710 cases in all ages for the same 35 year period at the Charity Hospital. Women were afflicted as commonly as men. Blacks outnumbered whites 2.9:l.O. Obstruction, pain, and weight loss of relatively short duration were prominent symptoms. Tumors tended to be located distally in the stomach, and scirrhous in appearance. Histologically, diffuse type lesions were more common than intestinal or other type tumors. Radiographic evidence of disease was usually present in patients undergoing upper gastrointestinal series. Endoscopy with biopsy was a valuable diagnostic tool. Resectability in this group was not less than that achieved for all ages, however, only one patient has survived for five years. Advanced stage lesions predominated and were associated with poor survival. Earlier stage lesions in this age group appear to bear a more favorable prognosis.
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## Transforming growth factor-โค1 (TGF-โค) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-โค treatment induced enhanced exp
Background and Objectives: Gastric carcinoma rarely affects young patients. This study was undertaken in order to clarify the clinicopathological features and prognosis of young patients with gastric carcinoma. Methods: The resected 107 specimens from 105 patients younger than 30 years of age with g
## Background and objectives: Some investigators have suggested that lung cancer in young patients has a more aggressive course and poorer prognosis than lung cancer in older patients. ## Methods: A retrospective review is presented of patients less than 40 years of age with bronchogenic carcinom