✦ LIBER ✦

Gas chromatographic/electron impact mass spectrometric selective confirmatory analysis of clenbuterol in human and bovine urine

✍ Scribed by Aldo Polettini; Angelo Groppi; M. Cristina Ricossa; Maria Montagna

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 383 KB
Volume: 22
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200220806

No coin nor oath required. For personal study only.

✦ Synopsis

A method for the confirmatory analysis of clenbuterol in human and bovine urine was developed. After a double washing of the acidified sample with fert-butyl methyl ether (only for bovine urine), and a solid-phase extraction with Bond-Elut Certify@ columns, derivatization was performed with trimethylboroxine. The extract was then analysed by gas chromatography/electron impact mass spectrometry. The advantages of the metbylboronate derivative with respect to other derivatives are discussed in terms of chromatographic properties and, above all, of specificity of the electron impact mass spectrum. The method was successfully used for the confirmatory analyses of clenbuterol during the XXV Olympic Games of Barcelona.

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