Gas chromatographic separation of saturated aliphatic hydrocarbon enantiomers on permethylated β-cyclodextrin

✍ Scribed by Uwe J. Meierhenrich; Mai-Julie Nguyen; Bernard Barbier; André Brack; Wolfram H.-P. Thiemann

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 88 KB
• Volume: 15
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.10269

✦ Synopsis

Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryostat-controlled gas chromatograph is described. The use of a cryogenic system allows the improvement of separations for various chiral aliphatic hydrocarbons. The molecular cyclodextrin-based mechanism of the achieved enantiomeric separations is discussed briefly. Possible applications of this analytical technique are summarized, with special emphasis on the planned enantiomeric separation experiment on a cometary nucleus.