Gas chromatographic determination of trisulfapyrimidines in tablets

✍ Scribed by John W. Turczan

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 263 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600570128

✦ Synopsis

A notiaqueous method of analysis utilizing chloroform as solvent has been developed for four conpounds and their dosage forms. The results obtained are in excellent agreement with those obtained by the official or manufacturers' methods, but the nonaqueous procedure is much more rapid.

Phenol-chloroform mixture was employed with good results as solvent for the analysis of two of the organic medicinal agents investigated.

N , N-Dimethylformamide-chloroform mixture was successfully utilized as a solvent system for the nonaqueous titration of four of the crystalline salts. However, the solvent could be applied only t o one dosage form.

A method based on precipitation of the amine as the tetraphenylborate and then estimating the tetraphenylborate by nonaqueous titrimetry was developed. This procedure does not have as wide an application as does direct nonaqueous titrimetry, but good analytical data were obtained for five of the dosage forms. This method would appear to be susceptible to excipient interference.