β Scribed by S.E. Swezey; T.F. Blaschke; P.J. Meffin
No coin nor oath required. For personal study only.
Pentazocine is an analgesic drug with 10-x abuse potential. Brotell et al.' have developed an electron-capture gas chromatographic assay for pentazocine which is both sensitive and reproducible. This paper describes several modifications of that assay which make it substantially faster and more convenient, while retaining the sensitivity and reproducibility of the original procedure. The method is applicable to whole blood, plasma or urine.
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Figure 3 Correlation diagram of canrenone concentrations obtained by automated extraction fluorimetry versus HPLC. Pooled normal human serum spiked with 50,100, and 150 ng/ml canrenone has been assayed by both methods.
Several methods for the determina tion of disopyramide have appeared in the literature. Fluorimetric analysis', gas-liquid chromatography with flame ion&zation2~3 or nitrogen-specific detecto?, and high-pressure liquid chromatography5 have been used.