Gap Junctions in Development and Disease

✍ Scribed by Klaus Willecke, Jürgen Eiberger (auth.), Professor Dr. Elke Winterhager (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2005
Tongue: English
Leaves: 288
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.

Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.

✦ Table of Contents

Connexin and Pannexin Genes in the Mouse and Human Genome....Pages 1-12
Essential Role of Gap Junctions During Development and Regeneration of Skeletal Muscle....Pages 13-27
Connexins in Cardiac Development: Expression, Role, and Transcriptional Control....Pages 29-55
Gap Junction and Connexin Remodeling in Human Heart Disease....Pages 57-82
Gap Junction Expression in Brain Tissues with Focus on Development....Pages 83-110
Connexins Responsible for Hereditary Deafness — The Tale Unfolds....Pages 111-134
Human Connexins in Skin Development and Skin Disorders....Pages 135-171
Intercellular Communication in Lens Development and Disease....Pages 173-195
Connexin Modulators of Endocrine Function....Pages 197-221
Roles of Gap Junctions in Ovarian Folliculogenesis: Implications for Female Infertility....Pages 223-237
Placental Connexins of Mice and Men....Pages 239-252
Connexins in Growth Control and Cancer....Pages 253-273

✦ Subjects

Cell Biology; Molecular Medicine; Developmental Biology; Otorhinolaryngology; Reproductive Medicine; Dermatology

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