Gap Junctions in Development and Disease

✍ Scribed by Elke Winterhager (Editor)

Publisher: Springer
Year: 2005
Tongue: English
Leaves: 288
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

✦ Table of Contents

Half-Title......Page 1
Inside Cover......Page 2
Copyright......Page 3
Preface......Page 4
Contents......Page 6
Contributors......Page 12
1 Connexin and Pannexin Genes in the Mouse and Human Genome......Page 17
2 Essential Role of Gap Junctions During Development and Regeneration of Skeletal Muscle......Page 29
3 Connexins in Cardiac Development: Expression, Role,andTranscriptionalControl......Page 44
Gap Junction and Connexin Remodeling in Human Heart Disease......Page 71
5 Gap Junction Expression in Brain Tissues with Focus on Development......Page 97
6 Connexins Responsible for Hereditary Deafness – The Tale Unfolds......Page 125
7 Human Connexins in Skin Development and Skin Disorders......Page 149
8 Intercellular Communication in Lens Development and Disease......Page 186
9 Connexin Modulators of Endocrine Function......Page 209
10 Roles of Gap Junctions in Ovarian Folliculogenesis: Implications for Female Infertility......Page 234
11 Placental Connexins of Mice and Men......Page 249
12 Connexins in Growth Control and Cancer......Page 263
Subject Index......Page 284

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