𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ga(OTf)3-promoted condensation reactions for 1,5-benzodiazepines and 1,5-benzothiazepines

✍ Scribed by Xiang-Qiang Pan; Jian-Ping Zou; Zhi-Hao Huang; Wei Zhang

Book ID
104095551
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
309 KB
Volume
49
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Condensation reactions of o-phenylenediamine and two equivalents of acetophenone under gallium(III) triflate catalysis produce biaryl-substituted 1,5-benzodiazepines. Similar reactions of o-phenylenediamine or o-aminothiophenol and o-hydroxy chalcones lead to formation of functionalized 1,5-benzodiazepines and 1,5-benzothiazepines in good to excellent yields. The ortho-hydoxy group of chalcones is crucial for this unprecedented condensation process.

📜 SIMILAR VOLUMES

Novel synthesis of 3-phenylazo-1,5-benzo
Novel synthesis of 3-phenylazo-1,5-benzothiazepines, -1,5-benzoxazepines and -1,5-benzodiazepines via a one-pot reaction
✍ Fawi M. Abd El Latif; Eman A. El-Rady; Mohamed A. Khalil; M. A. El-Maghraby 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 62 KB

## Abstract Novel polysubstituted ‐1,5‐benzothiazepine, ‐1,5‐benzoxazepine, and ‐1,5‐benzodiazepine were prepared in good yields by the reaction of hydrazono derivatives with __o__‐thioaminophenol, __o__‐aminophenol and __o__‐phenylenediamine __via__ a one‐pot reaction.