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Ganglioside composition of human neuroblastomas correlation with prognosis A pediatric oncology group study

✍ Scribed by Cara-Lynne Schengrund; Mary Ann Repman; Stephen J. Shochat

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
590 KB
Volume
56
Category
Article
ISSN
0008-543X

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✦ Synopsis

The ganglioside composition of neuroblastoma samples from 53 patients was determined. Tumor sites included the adrenal5 (15), and the thoracic (to), abdominal (15), and pelvic (3) areas. Age of the patients at the time of surgery ranged from 1 day to over 10 years and the Stage of the tumors from A to D. Differences in ganglioside patterns were observed, with neuroblastomas from patients who were either disease positive or dead of disease tending to have more monosialogangliosides and fewer gangliotetraose gangliosides of the B series (Gal-GalNAc-Gal-Clc-Cer, G I b , and Gal-GalNAc-Gal-Glc-Cer, GDIb) NeuNAc NeuNAc-NeuNAc NeuNAc-NeuNAc than tumors from patients who were disease-free. More specifically, six of the seven patients lacking G l b died of disease, suggesting that the absence of

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