Modified histologic grading of neuroblastomas by replacement of mitotic rate with Mitosis Karyorrhexis Index: A clinicopathologic study of 223 cases from the Pediatric Oncology Group
✍ Scribed by Vijay V. Joshi; Pejaver V. Rao; Alan B. Cantor; Geoff Altshuler; Jon J. Shuster; Robert P. Castleberry
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 707 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Histologic grading (HG) of neuroblastomas (NB) of prognostic significance is based on the presence or absence of calcification and low mitotic rate ( ~1 0 1 1 0 high power fields). Mitosis Karyorrhexis Index (MKI) is the main feature used for prognostic categorization in Shimada classification and can be determined more readily than mitotic rate (MR). The purpose of this study is to test whether MKI can be used instead of MR for histologic grading. METHODS. Low and intermediate MKI were lumped together as low MKI. We replaced MR with the modified MKI categories. The histologic grades for 223 NBs registered with the Pediatric Oncology Group protocols 8104 and 8441, were defined as follows: HG 1 = calcification + low MKI, HG 2 = calcification or low lanta, GA, CA