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Galanin: Structural requirements for binding and signal transduction in RINm5F insulinoma cells

✍ Scribed by B. Gallwitz; W.E. Schmidt; R. Schwarzhoff; W. Creutzfeldt


Book ID
117054946
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
617 KB
Volume
172
Category
Article
ISSN
0006-291X

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Thyrotropin-Releasing hormone (TRH)-degrading pyroglutamyl peptidase I (PGP I) and prolylendopeptidase (PE) activities have been demonstrated in rat insulinoma RINm 5F cell line. These two enzymes catalyze the conversion of TRH to Histydyl-Proline-Diketopiperazine and to acid TRH respectively. After