Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons
✍ Scribed by Xiling Ding; David MacTavish; Satyabrata Kar; Jack H. Jhamandas
- Book ID
- 118486331
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 619 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0969-9961
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The concept that galanin (GAL) is cosecreted with acetylcholine (ACh) into the ventral hippocampus is a major component of the current model delineating GAL regulation of the cholinergic memory pathways in the rat. Although GAL-immunoreactivity coexists in 50-70% of cholinergic neurons in the basal
Previous studies have indicated that galanin is one of the most abundant peptides in the basal forebrain and that it has a significant modulatory influence on cholinergic transmission. The aim of the present study was to use a light electron microscopic correlation technique to determine whether gal