Galactose-poly(ethylene glycol)-polyethylenimine for improved lung gene transfer
β Scribed by Jun Chen; Xiaoling Gao; Kaili Hu; Zhiqing Pang; Jia Cai; Jingwei Li; Hongbing Wu; Xinguo Jiang
- Book ID
- 116297258
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 778 KB
- Volume
- 375
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background Polyethylenimine (PEI) is toxic although it is one of the most successful and widely used gene delivery polymers with the aid of the proton sponge effect. Therefore, development of new novel gene delivery carriers having high efficiency with less toxicity is necessary. #
## Abstract An ideal gene carrier is required both in safety and efficiency for transfection. Polyethylenimine (PEI), a wellβstudied cationic polymer, has been proved with high transfection efficiency, but is reported as toxicity in many cell lines. In this study, PEI was coupled with polyethylene