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Poly(ethylene oxide) grafted with low molecular weight polyethylenimines for non-viral gene transfer

โœ Scribed by Meng Zheng; Lei Zhou; Ru Cheng; Fenghua Meng; Rui Peng; Zhiyuan Zhong

Book ID
113694791
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
266 KB
Volume
152
Category
Article
ISSN
0168-3659

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## Background: Poly(ethylene imine) (pei) is a widely used transfection reagent for mammalian cells, but in vivo application of pei 25 kda is restricted by its toxicity. low molecular weight (lmw) pei is less toxic, but also less efficient than its high molecular weight equivalent, and prone to agg