✦ LIBER ✦

Gain of function mutations in p53

✍ Scribed by Dittmer, Dirk; Pati, Sibani; Zambetti, Gerard; Chu, Shelley; Teresky, Angelika K.; Moore, Mary; Finlay, Cathy; Levine, Arnold J.

Book ID: 109915932
Publisher: Nature Publishing Group
Year: 1993
Tongue: English
Weight: 508 KB
Volume: 4
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng0593-42

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Protumorigenic overexpression of stathmi

Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis

✍ Stephan Singer; Volker Ehemann; Antje Brauckhoff; Martina Keith; Sebastian Vrede 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 742 KB

The microtubule (MT)-destabilizing protein stathmin/Op18 has previously been described to be negatively regulated by p53 and to be highly expressed in several tumor entities. However, little is known about its expression profile, functional or therapeutic relevance, and regulation in human hepatocar

Gain of Function of a p53 Hot Spot Mutat

Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

✍ Gene A. Lang; Tomoo Iwakuma; Young-Ah Suh; Geng Liu; V.Ashutosh Rao; John M. Par 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 582 KB

Downregulation of mutant p53 and severe

Downregulation of mutant p53 and severe growth inhibition mediated by antisense-oligonucleotides in pancreatic tumor cells indicate a ‘gain of function’—Type of mutation

✍ A. Fiedler; Y. Franke; B. Büsing; C. Röder; J. Lüttges; K. Bleicher; M. Maier; H 📂 Article 📅 1995 🏛 Springer-Verlag 🌐 English ⚖ 153 KB

794 Mutant P53 Functions in Vivo – Domin

794 Mutant P53 Functions in Vivo – Dominant-negative Effect is Cell-type Specific, Dose-dependent and Regulates Acute Response Whereas Gain-of-function Property is Mutation-type Specific

✍ K. Sabapathy; M.K. Lee; W.W. Teoh; W.M. Tong; Z.Q. Wang 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 55 KB

Deletions of BRCA1/2 and p53 R248W gain-

Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas

✍ K. Becker; M. Goldberg; P. Helmbold; L.M. Holbach; K.U. Loeffler; W.G. Ballhause 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 557 KB

p53 Mutations: Gains or losses?

✍ Dan Michalovitz; Orna Halevy; Moshe Oren 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 714 KB

Although the case for p53 as a tumor suppressor gene appears very strong, one should still keep an open eye for the possibility that mutations in p53 do not necessarily imply a mere loss of "suppressor" activity. It is still possible that the presence of a p53 mutation in a tumor contributes, in a d