Previous studies have shown that (\*) S 20244 (8-(4-[N-(5-methoxychroman-3-yl) N-propylamino] butyl) 8-azaspiro[4,5]decane-7,9 dione) and its isomers ( + ) S 20499 and (-) S 20500 are full agonists at 5-HT,, receptors. In the present study, the effects of these three compounds were investigated in t
GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures
β Scribed by Roy Corbett; Stuart Fielding; Michael Cornfeldt; Robert W. Dunn
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 810 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
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## Although noncompetitive NMDA receptor antagonists have shown an anxiolyticlike profile in several studies, such effects have not been observed consistently. Previous studies with ketamine, a noncompetitive NMDA antagonist, have employed only shock tests of anxiety based on conflict procedures. In
The effects of three 5HT3 receptor antagonists: BRL 43964 (0.1 and 1 mg/kg, oral), GR 38032F (0.1 and 1 mg/kg, oral), and zacopride (0.01, 0.1 and 1 mg/kg, IP) were examined in low light test conditions of the social interaction test. None of the three 5HT3 receptor antagonists had a significant eff