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G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

✍ Scribed by Jose Miguel Bras; Rita Joao Guerreiro; Maria Helena Ribeiro; Cristina Januario; Ana Morgadinho; Catarina Resende Oliveira; Luis Cunha; John Hardy; Andrew Singleton

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 70 KB
Volume: 20
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20682

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✦ Synopsis

Abstract

LRRK2 mutations have recently been described in families with Parkinson's disease. Here we show that one of them (G2019S) is present in 6% (7 of 124) unrelated cases of disease in a clinic‐based sample series from central Portugal, but not present in 126 controls from the same population. Thus, LRRK2 mutations appear to be a common cause of typical Parkinson's disease and as such will alter clinical practice. © 2005 Movement Disorder Society

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