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G1 to S transition: more than a cell cycle engine switch

✍ Scribed by Crisanto Gutierrez; Elena Ramirez-Parra; M.Mar Castellano; J.Carlos del Pozo

Book ID: 114394721
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 83 KB
Volume: 5
Category: Article
ISSN: 1369-5266
DOI: 10.1016/s1369-5266(02)00301-1

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## Genetic intervention in cell-cycle regulation is a promising strategy to obtain mammalian cell culture proliferation in the absence of exogenous growth factors. In order to gain insights into this approach, known interactions among the four proteins cyclin E, cdk2, the retinoblastoma gene produ