𝔖 Bobbio Scriptorium
✦   LIBER   ✦

G-CSF-induced remission in two cases of acute myeloid leukemia

✍ Scribed by Rudolf Benz; Jeroen S. Goede; Valérie Parlier; Dominique Mühlematter; Martine Jotterand; Jörg Fehr

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
395 KB
Volume
32
Category
Article
ISSN
0145-2126

No coin nor oath required. For personal study only.

✦ Synopsis

We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.

📜 SIMILAR VOLUMES

Complete remission in three patients wit
Complete remission in three patients with acute myeloblastic leukemia by administration of G-CSF without antileukemic agents
✍ Takahashi, Masuhiro; Koike, Tadashi; Aizawa, Yoshifusa; Kashimura, Makoto; Hayat 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB 👁 2 views

We describe 3 patients with acute myeloblastic leukemia (AML), who received rhG-CSF for infections such as pneumonia or for prophylaxis of infection, and who achieved complete remission. They had not received any antileukemic therapy before or during the administration of rhG-CSF. These findings sug

Fludarabine, cytarabine, and G-CSF (FLAG
Fludarabine, cytarabine, and G-CSF (FLAG) for the treatment of poor risk acute myeloid leukemia
✍ Montillo, Marco; Mirto, Salvatore; Petti, Maria Concetta; Latagliata, Roberto; M 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB 👁 2 views

Thirty-eight patients with primary resistant or relapsing acute myeloid leukemia (AML) were treated with fludarabine, cytarabine and granulocyte colony-stimulating factor (FLAG). Median age was 41 (range 11-70). Sixteen patients had AML that was primary resistant to induction treatment, while 22 wer

Impact of remission induction chemothera
Impact of remission induction chemotherapy on survival in older adults with acute myeloid leukemia
✍ Rachid Baz; Cristina Rodriguez; Alex Z. Fu; Rony Abou Jawde; Matt Kalaycio; Anja 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 2 views

## Abstract ## BACKGROUND. Significant controversy surrounds the use of remission induction chemotherapy (IC) in older adults with acute myeloid leukemia (AML). Earlier clinical trials have yielded conflicting results and possibly a minor survival benefit, often offset by a longer hospitalization

Potential cure of acute myeloid leukemia
Potential cure of acute myeloid leukemia : Analysis of 1069 consecutive patients in first complete remission
✍ Masamitsu Yanada; Guillermo Garcia-Manero; Gautam Borthakur; Farhad Ravandi; Hag 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB

## Abstract ## BACKGROUND. Potential cure of acute myeloid leukemia (AML) is now a widely accepted idea, but it is uncertain whether there is heterogeneity in the failure rate in patients once they have been in complete remission (CR) for various periods of time. ## METHODS. The long‐term outcom