Fuzziness: Structural Disorder in Protein Complexes

✍ Scribed by Monika Fuxreiter, Peter Tompa (auth.), Monika Fuxreiter PhD, Peter Tompa PhD (eds.)

Publisher: Springer-Verlag New York
Year: 2012
Tongue: English
Leaves: 210
Series: Advances in Experimental Medicine and Biology 725
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

✦ Table of Contents

Front Matter....Pages i-xx
Fuzzy Complexes: A More Stochastic View of Protein Function....Pages 1-14
Dynamic Fuzziness During Linker Histone Action....Pages 15-26
Intrinsic Protein Flexibility in Regulation of Cell Proliferation: Advantages for Signaling and Opportunities for Novel Therapeutics....Pages 27-49
Interplay Between Protein Order, Disorder and Oligomericity in Receptor Signaling....Pages 50-73
Consequences of Fuzziness in the NFκB/IκBα Interaction....Pages 74-85
Roles for Intrinsic Disorder and Fuzziness in Generating Context-specific Function in Ultrabithorax, a Hox Transcription Factor....Pages 86-105
Molecular Recognition by the EWS Transcriptional Activation Domain....Pages 106-125
The Measles Virus N TAIL -XD Complex: An Illustrative Example of Fuzziness....Pages 126-141
Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV....Pages 142-158
Structural Disorder and Protein Elasticity....Pages 159-183
“Fuzziness” in the Celular Interactome: A Historical Perspective....Pages 184-190
Back Matter....Pages 191-194

✦ Subjects

Biomedicine general; Molecular Medicine

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