## Abstract Enzymatic synthesis of cefaclor was carried out with kinetic control. The product yield was improved by the continuous removal of product from the reaction mixture via complexation of cefaclor with 1βnaphthol. The effects of pH and temperature on the enzymatic and complexing reactions w
Future directions for in-situ product removal (ISPR)
β Scribed by John M Woodley; Marc Bisschops; Adrie J J Straathof; Marcel Ottens
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2008
- Tongue
- English
- Weight
- 114 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0268-2575
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β¦ Synopsis
Abstract
This paper summarizes the main findings of a roundβtable discussion held to examine the key bottlenecks in the further application and industrial implementation of inβsitu product removal (ISPR) techniques.** It is well established that ISPR can yield great benefits for processes limited by inhibitory or toxic products, as well as unstable products or reactions that are thermodynamically unfavorable. However, several issues for industrial implementation were revealed in the discussion. Most notably implementation will be dependent on (1) research into the appropriate process structure, (2) methods to achieve process robustness, (3) systematic selection methods for separation operations and (4) the nature of the product market. Here, these four issues will be discussed as a basis for future work in this area. Copyright Β© 2007 Society of Chemical Industry
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