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Fusion of dendritic cells with multiple myeloma cells results in maturation and enhanced antigen presentation

✍ Scribed by Baldev Vasir; Virginia Borges; Zekui Wu; Daren Grosman; Jacalyn Rosenblatt; Masaki Irie; Kenneth Anderson; Donald Kufe; David Avigan

Book ID: 108673195
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 457 KB
Volume: 129
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2005.05507.x

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We investigated whether dendritic cells (DCs) from multiple myeloma (MM) patients were affected by loading tumor antigens and whether the defective DC function associated with MM could be overcome by the neutralization of VEGF. MM-specific DCs were generated by loading tumor lysates from myeloma cel