Further studies on carbon catabolite regulation of β-lactam antibiotic synthesis inCephalosporium acremonium
✍ Scribed by Clifford J. Behmer; Arnold L. Demain
- Book ID
- 105242915
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 572 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0343-8651
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Synthesis of optically active 3'-nor-type 1-oxacephems from 6-APA was described. R-Nitrobenzyl 7B-amino-3-chloro-7a-methoxy-l-oxa-3-cephem-4-carboxylate 39 was also prepared. - et al. 2a described that some 3-norcephalosporins showed antibacterial activity equivalent to naturally occurring cephalo
Alcohols 4\_ and s prepared from 3 underwent completely stereospecific etherification to give l-oxacephams 2 and s which were converted into the 1-oxacephem nucleus 2 via kaand lc. Functionalization at C-3' in 6 and &was unsuccessful. Since 7a-methoxy-1-oxacephem & (6059-S) was found to be a highly