Further genetic variability of the VNTR D1S80 (pMCT118): Correspondence analysis studies

✍ Scribed by J. R. Luis; B. Caeiro

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 453 KB
• Volume: 8
• Category: Article
• ISSN: 1042-0533
• DOI: 10.1002/(sici)1520-6300(1996)8:1<81::aid-ajhb7>3.0.co;2-t

✦ Synopsis

A population genetic study of the VNTR D1S80 (pMCT118 locus) in 206 individuals from the Galician population in Spain was carried out. PCR amplified DNA were electrophoresed in horizontal polyacrylamide gels and subsequently were visualized by silver staining. Up to 19 alleles in 56 different genotypes were found. This report describes a new allele tentatively named T11 that defines the lower limit of repeats reported for this VNTR. A family study demonstrates autosomal codominant inheritance of this allele. Levels of heterozygosity indexes are about 80%. No significant deviations from Hardy-Weinberg equilibrium were observed, using the allele binning method (P > 0.3 in all cases). Correspondence analysis shows the usefulness of D1S80 alleles in the genetic profiling of human populations, with the alleles 16, 17, 21, 29, and 31 being of particular interest at different levels of analysis. © 1996 Wiley-Liss, Inc.