Further advances in the synthesis of endocannabinoid-related ligands
β Scribed by Anu Mahadevan; Raj K. Razdan
- Book ID
- 111766816
- Publisher
- American Association of Pharmaceutical Scientists
- Year
- 2005
- Tongue
- English
- Weight
- 212 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1550-7416
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The intramolecular cyclopropanation of Ξ²,Ξ³-unsaturated metalated epoxides derived from 11 yielded the highly strained tricyclic intermediates 7. The facile hydrolysis of the latter species afforded the Ξ±-keto spirocyclopropanes 8 in a stereospecific fashion. Indeed, the stereochemistry of the
Bis(oxazoline) ligands have been used to prepare chiral catalysts for a large variety of enantioselective reactions. This versatility has attracted interest towards its immobilization, to profit from the advantages of using heterogeneous catalysis with respect to catalyst separation, possible recycl