Furan induction of DNA cross-linking and strand breaks in turkey fetal liver in comparison to 1,3-propanediol
β Scribed by Alan M. Jeffrey; Klaus D. Brunnemann; Jian-Dong Duan; Josef Schlatter; Gary M. Williams
- Book ID
- 116464046
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 284 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0278-6915
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2-Acetylaminofluorene (AAF) or trans-4-acetylaminostilbene (AAS) was orally or intraperitoneally administered to female Wistar rats. DNA from liver cells was analyzed for single-strand breaks by the alkaline elution assay. Only borderline effects were observed with doses (100 pmol/kg) used in animal
Levels of DNA strand breaks and DNA-protein cross-links (DPCs) were measured using the alkaline elution assay in normal human skin fibroblasts irradiated with 0-200 J m-2 of 254 nm UV radiation and incubated for 0-24 h. On incubation, the yields of both single-strand breaks (SSBs) and DPCs increased