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Furan Based Cyclic Oligopeptides Selectively Target G-Quadruplex

✍ Scribed by Chakraborty, Tushar Kanti; Arora, Amit; Roy, Saumya; Kumar, Niti; Maiti, Souvik

Book ID
124158775
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
107 KB
Volume
50
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES

Furan based cyclic homo-oligopeptides bi
Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription
✍ Tani Agarwal; Saumya Roy; Tushar Kanti Chakraborty; Souvik Maiti πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 390 KB

We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in t