Fungal Phenalenones Inhibit HIV-1 Integrase
β Scribed by Shiomi, Kazuro; Matsui, Ryosuke; Isozaki, Miki; Chiba, Harumi; Sugai, Takahiro; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Chiba, Tomoko; Yan, Hua
- Book ID
- 109867682
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 106 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0021-8820
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The HIVβ1 Integrase protein (IN) mediates the integration of the viral cDNA into the host genome. IN is an emerging target for antiβHIV drug design, and the first INβinhibitor was recently approved by the FDA. We have developed a new approach for inhibiting IN by βshiftidesβ: peptides d
## Abstract ## Background HIVβ1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi