The synthesis of both enantiomers of phosphonothrixin is described. On the basis of optical rotation and biological activity, the natural product was determined to have S configuration.
Fungal metabolism of (±)-epoxyfarnesol and its absolute stereochemistry
✍ Scribed by Yoshikatsu Suzuki; Shingo Marumo
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 183 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We wish to report that the metabolic transformation of (?Z)-epoxyfarnesol (I) by Helminthosporium sativum yielded (-)-lO,ll-dihydroxyfarnesol (II), (-)-lO,ll-dihydroxyfarnesic acid (III) and (-)-9,10-dihydroxygeranylacetone (IV), and that their absolute stereochemistry, as well as
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## Abstract For Abstract see ChemInform Abstract in Full Text.
IN an earlier communicationl, we reported on the structure elucidation of hardwickiic acid (I) and some other related diterpenoids, all constituents of the oleo-resin of Hardwickia pinnata. However, biogenetic considerations were invoked for the placement of the angular methyla as shown in I. We now