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Functionalized ketones by iron mediated reaction of grignard reagents with acyl chlorides

✍ Scribed by C. Cardellicchio; V. Fiandanese; G. Marchese; L. Ronzini

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 219 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96043-x

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✦ Synopsis

The iron(:II)-catalyzed cross-coupling reaction between Grignard reagents and acyl ___chlorides was found to be widely applicable to the synthesis of various functionalized ketones in good yields under mild conditions; the series of examples includes the synthesis of chiral methyl ketones and symmetric diketones.

In a previous work', we have reported a simple and versatile synthesis leading to ketones in high yields and without concomitant formation of alcohols.

The procedure involves a

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