Iron catalyzed cross-coupling reactions of acyl chlorides with Grignard reagents. A mild, general, and convenient synthesis of aliphatic and aromatic ketones.

✍ Scribed by V. Fiandanese; G. Marchese; V. Martina; L. Ronzini

• Publisher: Elsevier Science
• Year: 1984
• Tongue: French
• Weight: 197 KB
• Volume: 25
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81525-2

✦ Synopsis

TABLE Cross-Coupling Reactions of Acyl Chlorides with Grignard Reagents in the Presence of Fe(acac)3 as a Catalysta. R-C+ 0 3% Fe(acac)3 0 + 'Cl R'MgXb THF R-C< R' Entry R R' Temp Yield in KetoneC % 1 CH3(Ct& CH3 r.t. 84 2 CH3(CH2)4 CH3(C"2)4 r.t. 82 3 CH3 CH3(CH2)8 r.t. 82 4 CH3 CH3(CH2)9 r.t. 80 5 CH3(CH2)2 (CH3)2CH r.t. 80 zato di Chimica Fine e Secondaria" of Italian National Research Council (CNR), Rome.