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Functionalized Hydantoins as Potential Antibiotics

✍ Scribed by Jacqueline Marchand-Brynaert; Edith Amadei; Leon Ghosez

Book ID
101762113
Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
437 KB
Volume
103
Category
Article
ISSN
0037-9646

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✦ Synopsis

racemic compounds 19a-c, prepared in six steps from 5-oxohydantoin, were inactive onto bacterial tests.

The 5-acylamino-3-acetylhydantoin derivatives 8 were designed as potential antibiotics mimicking lactivicin 1. The

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The bicyclic imidazolidinones 5 topologically related to the penicillin family, are susceptible to form a stable carbamate with serine-D,D-peptidases. A series of N-7 acylated or sulfonylated (2R, 5R)-3,3-dimethyl-8-oxo-4-thia-7,l -diazabicyclo[3.3.0]octane-2-carboxylates 2-a have been prepared. Non