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Bicyclic imidazolidinones as potential antibiotics

✍ Scribed by Jacqueline Marchand-Brynaert; Huguette Vanlierde; Léon Ghosez

Book ID
102773551
Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
858 KB
Volume
97
Category
Article
ISSN
0037-9646

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✦ Synopsis

The bicyclic imidazolidinones 5 topologically related to the penicillin family, are susceptible to form a stable carbamate with serine-D,D-peptidases. A series of N-7 acylated or sulfonylated (2R, 5R)-3,3-dimethyl-8-oxo-4-thia-7,l -diazabicyclo[3.3.0]octane-2-carboxylates 2-a have been prepared. None of these novel penicillin analogs exhibited antibacterial activity.

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