To differentiate between the "intact" and "sick" cell hypo€he& explaining decreased clearance of endo-and xenobbtics, we meaeured uptake of taurocholate and OIlQBOill in hepatocytes isolated from cirrhotic rat liver. Cirrhouis was induced by chronic exposure of male Sprague-Dawley rats to phenobarbi
Functional properties of isolated hepatocytes from ethanol-treated rat liver
✍ Scribed by Amador Schüller; Jorge Moscat; Emilio Diez; Jose C. Fernandez-Checa; Francisco G. Gavilanes; Angel M. Municio
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 630 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Cluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol-treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol-treated animals; palmitate incorporation into triacylglycerols increased. In ethanol-treated rat liver, "Caz* uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.
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