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Functional p53 determines docetaxel sensitivity in prostate cancer cells

✍ Scribed by Chengfei Liu; Yezi Zhu; Wei Lou; Nagalakshmi Nadiminty; Xinbin Chen; Qinghua Zhou; Xu Bao Shi; Ralph W. deVere White; Allen C. Gao

Book ID
115561376
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
899 KB
Volume
73
Category
Article
ISSN
0270-4137

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## Abstract Gemcitabine is a relatively new agent with promising activity in solid tumors. Few data are available regarding mechanisms of resistance to gemcitabine downstream from the drug‐target interaction. The present study was performed to gain insight into the role of p53 status on the cytotox