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Functional outcome of intrathecal baclofen administration for severe spasticity

✍ Scribed by Efstathios J. Boviatsis; Andreas T. Kouyialis; Stefanos Korfias; Damianos E. Sakas

Book ID
116368839
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
170 KB
Volume
107
Category
Article
ISSN
0303-8467

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The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize