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Functional Organization and Conformational Dynamics of the Nicotinic Receptor : A Plausible Structural Interpretation of Myasthenic Mutations

โœ Scribed by Antoine Taly; Jean-Pierre Changeux


Book ID
111483674
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
600 KB
Volume
1132
Category
Article
ISSN
0890-6564

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## Monoclonal antibodies against the main immunogenic region (MIR) of the muscle acetylcholine receptor (AChR) are capable of inducing experimental myasthenia gravis ( M G ) in animals. The epitope of these antibodies has been localized between residues 67 and 76 of the AChR a-subunit. The conformat