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Structural and functional studies of the nicotinic acetylcholine receptor by solid-state NMR

✍ Scribed by P. T. F. Williamson; B. H. Meier; A. Watts


Book ID
105946054
Publisher
Springer
Year
2004
Tongue
English
Weight
360 KB
Volume
33
Category
Article
ISSN
1432-1017

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The interaction of diisopropylfluorophosphate (DFP) with the nicotinic acetylcholine (ACh) receptor of Torpedo electric organ was studied, using [3H]-phencyclidine ([3H]-PCP) as a reporter probe. Phencyclidine binds with different kinetics to resting, activated, and desensitized receptor conformatio