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Functional organ preservation after chemoradiotherapy in elderly patients with loco-regionally advanced head and neck squamous cell carcinoma

✍ Scribed by Paolo Boscolo-Rizzo; Enrico Muzzi; Franco Trabalzini; Alessandro Gava; Marco Stellin; Maria Cristina Da Mosto

Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
164 KB
Volume
268
Category
Article
ISSN
0302-9530

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## Abstract ## Background: Activation of the mammalian target of rapamycin (mTOR) pathway in surgical margins of head and neck squamous cell carcinoma (HNSCC) is a predictor of recurrence and patients with minimal residual disease may benefit from adjuvant therapy with temsirolimus, an mTOR inhibi